Bulletin of Stomatology and Maxillofacial Surgery
ISSN 1829-006X
2025; 216–221
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DECODING AUTISM:THE SCIENTIFIC LINK BETWEEN SALIVARY VITAMIN D3 LEVELS AND NEURODEVELOPMENT-A CASE-CONTROL STUDY

Divya Dharshini*

Received: 2026-04-08 · Published: 2025-04-30

© 2025 The Author(s) and the original publisher.

CC BY-NC 4.0 This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
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Original title
DECODING AUTISM:THE SCIENTIFIC LINK BETWEEN SALIVARY VITAMIN D3 LEVELS AND NEURODEVELOPMENT-A CASE-CONTROL STUDY
Author
Divya Dharshini
Source journal
Bulletin of Stomatology and Maxillofacial Surgery
Published
2025-04-30
Licence
Creative Commons Attribution-NonCommercial 4.0 International
Original
https://doi.org/10.58240/1829006X-2025.3-216

Abstract

Objective: Autism Spectrum Disorder (ASD) involves challenges in social communication and repetitive behaviors. Emerging evidence suggests a link between vitamin D3, vital for brain function, and ASD, though research on salivary vitamin D3 as a biomarker in ASD is limited. Aim:To compare salivary vitamin D3 levels between ASD patients and neurotypical individuals. Materials and Methods: This case-control study collected unstimulated saliva samples from ASD patients and neurotypical controls. Vitamin D3 levels were measured using enzyme-linked immunosorbent assay (ELISA), with paired t-tests for group comparisons. Results: ASD patients had significantly lower salivary vitamin D3 levels than controls (p = 0.001), with ranges of 28.9–48.4 ng/mL in ASD versus 45.2–60.9 ng/mL in neurotypical individuals. Conclusion:ASD patients showed lower salivary vitamin D3, suggesting a potential association with vitamin D3 deficiency. Further research could explore the role of vitamin D3 in ASD and assess the benefits of monitoring and supplementation.
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