DETERMINATION OF BINDING ENTHALPY VALUE AT COMPLEX-FORMATION OF LIGAND WITH DNA

S.N. Hakobyan

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Submitted: 2025-03-10; Published: 2016-07-01

This work is licensed under Creative Commons Attribution–NonCommercial International License (CC BY-NC 4.0).

Abstract

The value of binding enthalpy change (ΔH) due to DNA–ligand complexformation has been determined by Van’t–Hoff mode having dependence of binding constant (K) on the reverse value of absolute temperature. Calculations that were carried out for DNA–ethidium bromide and DNA–mitoxantrone complexes showed, that if ΔH is determined from the values of K at two different temperatures, the calculated value of ΔH in the error frame coincides with its experimental value.

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DETERMINATION OF BINDING ENTHALPY VALUE AT COMPLEX-FORMATION OF LIGAND WITH DNA

Abstract

Author(s)

Table of Contents

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DETERMINATION OF BINDING ENTHALPY VALUE AT COMPLEX-FORMATION OF LIGAND WITH DNA

Abstract

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