2016; Chemical and Biological Sciences 50 (2 (240): 51–54
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DETERMINATION OF BINDING ENTHALPY VALUE AT COMPLEX-FORMATION OF LIGAND WITH DNA

S.N. Hakobyan*

Received: 2025-03-10 · Published: 2016-07-01

© 2016 The Author(s) and the original publisher.

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Original title
DETERMINATION OF BINDING ENTHALPY VALUE AT COMPLEX-FORMATION OF LIGAND WITH DNA
Author
S.N. Hakobyan
Published
2016-07-01
Licence
as stated by the publisher

Abstract

The value of binding enthalpy change (ΔH) due to DNA–ligand complexformation has been determined by Van’t–Hoff mode having dependence of binding constant (K) on the reverse value of absolute temperature. Calculations that were carried out for DNA–ethidium bromide and DNA–mitoxantrone complexes showed, that if ΔH is determined from the values of K at two different temperatures, the calculated value of ΔH in the error frame coincides with its experimental value.
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