Department of Oral Pathology and Microbiology Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai · Department of Oral Biology, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences (SIMATS), Chennai-600 077, India · Department of Biochemistry, Centre of Molecular Medicine and Diagnostics (COMManD), Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences (SIMATS), Chennai-600 077, India
Background: Oral Submucous Fibrosis (OSMF) is a chronic, progressive disorder characterized by inflammation and fibrosis of the oral mucosa, resulting in restricted mouth opening, pain, and burning sensations. Current interventions for OSMF are limited by suboptimal efficacy and poor patient compliance, emphasizing the need for alternative therapeutic strategies. The present study aimed to develop and evaluate a novel medicated chewing gum formulation incorporating Angelica dahurica, a medicinal herb recognized for its anti-inflammatory and hepatoprotective properties, as a potential management approach for OSMF.
Objective: A medicated chewing gum was formulated using Angelica dahurica extract as the primary active ingredient. Characterization was carried out using Fourier-transform infrared spectroscopy (FTIR) to confirm the presence of functional groups, Thermogravimetric analysis (TGA) to determine the thermal stability of the product,
Contact angle measurements, to evaluate surface wettability and Antimicrobial efficacy against Enterococcusfaecalis, Candida albicans, and Streptococcus mutans was assessed using standard assay protocols.
Materials and Methods: A prospective research of the next ten cases treated under the same circumstances (7 men, 3 women, average age of 20.8 +2.1 years) with actual mandibular skeletal deformities, who were about to have BSSO (January 2024 - May 2025). Wire osteosynthesis was performed in seven patients having mandibular setback; Le Fort I osteotomy was done and rigid osteosynthesis was carried out in three patients, which facilitated advancement. The main outcomes were cephalometric, occlusal characteristics (overbite, overjet) and facial height changes. Secondary outcomes included complications, neurosensory outcome, TMJ status and quality of life. Stability was measured by using extended follow up (mean of 18.2 6.3months).
Results: FTIR analysis confirmed the presence of functional groups such as carbonyl and aromatic groups within the gum formulation. Thermogravimetric analysis revealed that the gum maintains structural stability up to 300°C, with thermal decomposition apparent at higher temperatures. The contact angle findings indicated a distinctly hydrophilic surface, suggesting suitability for effective mucosal delivery of the active ingredient. Antimicrobial testing revealed significant inhibitory activity against the tested pathogenic microorganisms.
Conclusions: The study demonstrates that medicated chewing gum formulated with Angelica dahurica possesses favorable chemical, thermal, surface, and antimicrobial properties that provides a promising alternative therapeutic option for treating OSMF.
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