Bulletin of Stomatology and Maxillofacial Surgery
ISSN 1829-006X
2025; 71–85
Shared with The Gufo

EFFICACY OF LAETRILE IN TREATMENT OF CANCER PATIENTS WITH CHEMORADIATION ORAL MUCOSITIS

Inessa Romanenko*, Kristina Arakelyan

Head of the Department of Stomatology, Faculty of Training of Highly Qualified Medical Personnel and Continuing Professional Education V.I. Vernadsky Kazan Federal University, Simferopol, Republic of Crimea, RF · PhD, Department of Stomatology, Faculty of Training of Highly Qualified Medical Personnel and Continuing Professional Education V.I. Vernadsky Kazan Federal University, Simferopol, Republic of Crimea, RF

Received: 2026-04-08 · Published: 2025-05-20

© 2025 The Author(s) and the original publisher.

CC BY-NC 4.0 This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Shared article.
Original title
EFFICACY OF LAETRILE IN TREATMENT OF CANCER PATIENTS WITH CHEMORADIATION ORAL MUCOSITIS
Authors
Inessa Romanenko, Kristina Arakelyan
Source journal
Bulletin of Stomatology and Maxillofacial Surgery
Published
2025-05-20
Licence
Creative Commons Attribution-NonCommercial 4.0 International
Original
https://doi.org/10.58240/1829006X-2025.21.4-71

Abstract

Background: Post-chemoradiation mucositis is a common and serious side effect that occurs in patients undergoing cancer treatment. It is an inflammatory condition of the mucous membrane that can cause significant discomfort, pain, and a significant reduction in quality of life. Among the many methods used to relieve and treat mucositis, the drug Laetrile has attracted particular attention due to its potential therapeutic properties. The aim of this study was to evaluate the effectiveness of Laetrile in treating post-chemoradiation mucositis. Materials and Methods;The study involved 89 patients diagnosed with cancer of the oral mucosa (C00-C06, C10, C13, C14 according to ICD-10) stages II and III (T2-3, N0-1, M0), aged 55 to 67 years, who received chemoradiation therapy to the head and neck area. Depending on the treatment method, patients were divided into two groups: comparison traditional treatment) and the main (developed method that reduced the incidence of bleeding gums, erosions and ulcers of the oral mucosa. Results: The use of Laetrile allowed to achieve a therapeutic-prophylactic effect in 55 (93.2%) of 89 patients treated with Laetrile while in the comparison group (traditional treatment) in 19 (63.3%) of 30 patients Conclusion: Laetrile is an interesting alternative in the treatment of postchemoradiation mucositis thanks to its potential ability to reduce inflammation and promote tissue regeneration. Thus, although Laetrile is a promising option for managing the symptoms of mucositis, its potential benefits and risks have yet to be clarified in further research.
1 / ? 100% Open in new tab Download Cite

Loading the full text…

Download Follow Updates