Bulletin of Stomatology and Maxillofacial Surgery
ISSN 1829-006X
2025; 1–12
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EVALUATION OF ANTIBACTERIAL AND ANTI-INFLAMMATORY EFFECT OF GREEN SYNTHESIZED SILVER OXIDE NANOPARTICLES FROM MANILKARA LITTORALIS FOR BIOMEDICAL APPLICATIONS

Mohammad Nemat Sache*, Hema Saheb Ali, Saheb Ali

Saveetha University

Received: 2026-04-08 · Published: 2025-11-10

© 2025 The Author(s) and the original publisher.

CC BY-NC 4.0 This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
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Original title
EVALUATION OF ANTIBACTERIAL AND ANTI-INFLAMMATORY EFFECT OF GREEN SYNTHESIZED SILVER OXIDE NANOPARTICLES FROM MANILKARA LITTORALIS FOR BIOMEDICAL APPLICATIONS
Authors
Mohammad Nemat Sache, Hema Saheb Ali, Saheb Ali
Source journal
Bulletin of Stomatology and Maxillofacial Surgery
Published
2025-11-10
Licence
Creative Commons Attribution-NonCommercial 4.0 International
Original
https://doi.org/10.58240/1829006X-2025.21.10-330

Abstract

Objective:This study investigates the antibacterial and anti-inflammatory effects of silver oxide nanoparticles (AgO NPs) synthesized using a green approach with Manilkara littoralis extract, highlighting their potential in biomedical applications. Methods:AgO NPs were synthesized by reducing silver nitrate with Manilkara littoralis leaf extract, confirmed by color change. Characterization involved FTIR, UV-Vis spectroscopy, XRD, and SEM. Antibacterial efficacy was assessed against S. aureus and E. coli using the disk diffusion method, while anti-inflammatory properties were tested in a zebrafish model. Results:AgO NPs exhibited strong antibacterial activity, especially against Gram-positive bacteria. Antiinflammatory effects were observed in zebrafish embryos with minimal adverse impacts, indicating favorable biocompatibility. Conclusions:AgO NPs synthesized from Manilkara littoralis show promise as a dual-function therapeutic agent for potential biomedical applications, particularly in infection control and inflammation management. Further research is needed to explore their full clinical potential.
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