Bulletin of Stomatology and Maxillofacial Surgery
2025; 198–212
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EVALUATION OF HEMOCOMPATIBILITY AND CYTOCOMPATIBILITY NOVEL CISSUS QUADRANGULARIS, BIOCERAMICS AND TENDON EXTRACELLULAR MATRIX INCORPORATED SCAFFOLDS FOR PERIODONTAL BONE REGENERATION

Balaji Ganesh Subramanian*, Tamanna Kaur, Taniya Martin, Gurumoorthy Kaarthikeyan, Meenakshi Kumar

Reader, Department of Periodontics, Saveetha Dental College and hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai-600077, Tamil Nadu, India · Undergraduate, Department of Periodontics, Saveetha Dental College and hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai-600077, Tamil Nadu, India · Research Scholar Saveetha Dental College and hospitals, Department of Anatomy Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai-600077, Tamil Nadu, India · Professor and Head of Department, Department of Periodontics, Saveetha Dental College and hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai-600077, Tamil Nadu, India · .Assistant Professor, Department of Anatomy Saveetha Dental College and hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai-600077, Tamil Nadu, India

Received: 2025-10-02 · Published: 2025-08-16

© 2025 The Author(s) and the original publisher.

CC BY-NC 4.0 This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
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Original title
EVALUATION OF HEMOCOMPATIBILITY AND CYTOCOMPATIBILITY NOVEL CISSUS QUADRANGULARIS, BIOCERAMICS AND TENDON EXTRACELLULAR MATRIX INCORPORATED SCAFFOLDS FOR PERIODONTAL BONE REGENERATION
Authors
Balaji Ganesh Subramanian, Tamanna Kaur, Taniya Martin, Gurumoorthy Kaarthikeyan, Meenakshi Kumar
Source journal
Bulletin of Stomatology and Maxillofacial Surgery
Published
2025-08-16
Licence
Creative Commons Attribution-NonCommercial 4.0 International
Original
https://doi.org/10.58240/1829006X-2025.21.7-198

Abstract

This study presents the fabrication and evaluation of a novel bioactive scaffold integrating Cissus quadrangularis extract, carrageenan, tendon-derived extracellular matrix (ECM), and bioactive ceramics such as silver hydroxyapatite and silver tricalcium phosphate for periodontal bone regeneration. The scaffold’s biocompatibility was evaluated using MTT assay, while mineralization capacity was assessed via Alizarin Red S staining. Hemocompatibility was tested to ensure safe interaction with blood components. Furthermore, osteogenic potential was investigated through quantitative PCR analysis of key markers: RUNX2, ALP, OCN, COL1A1, and BMP2 using osteoblastoma cell lines. Results demonstrated high cell viability, minimal haemolytic activity, enhanced mineral deposition, and significant upregulation of osteogenic genes, particularly in group 4 containing tendon ECM and silver tricalcium phosphate. The findings support the scaffold’s potential for clinical use in periodontal bone defect repair, offering a costeffective and multifunctional approach for regenerative dentistry.
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