THE NEW ARMENIAN MEDICAL JOURNAL Volume19 (2025), Issue 3
2025; 44–56
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EVALUATION OF THE ANTIBACTERIAL ACTIVITY OF CYNARA SCOLYMUS EXTRACT AND ITS WOUND HEALING POTENCY AGAINST MULTIDRUG-RESISTANT ACINETOBACTER BAUMANNII, IN VITRO AND IN VIVO STUDY

Milad Shahsafi*, Hamid Reza Mohajerani, Majid Akbari, M. Madrnia

Microbiology Department, Science Faculty, Science and Research Branch, Islamic Azad University, Arak, Iran · Applied neuroscience research center, Islamic Azad University, Arak, Iran · Arak Infectious Diseases Research Center (IDRC) Arak Brunch, Islamic Azad University/ Arak University of Medical Siences, Arak Iran · Department of Biology. Payame Noor University (PNU), Arak University of medical sciences, Arak Branch, Islamic Azad University, Tehran, Iran

Received: 2025-09-01 · Published: 2025-05-15

© 2025 The Author(s) and the original publisher.

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Original title
EVALUATION OF THE ANTIBACTERIAL ACTIVITY OF CYNARA SCOLYMUS EXTRACT AND ITS WOUND HEALING POTENCY AGAINST MULTIDRUG-RESISTANT ACINETOBACTER BAUMANNII, IN VITRO AND IN VIVO STUDY
Authors
Milad Shahsafi, Hamid Reza Mohajerani, Majid Akbari, M. Madrnia
Source journal
THE NEW ARMENIAN MEDICAL JOURNAL Volume19 (2025), Issue 3
Published
2025-05-15
Licence
as stated by the publisher
Original
https://doi.org/10.56936/18290825-3.19v.2025-44

Abstract

Objectives: Plants extracts known as phytomedicine have immense potential for the management and treatment of wounds. Aim of this study was evaluate the antimicrobial effect and wound healing potency of Cynara scolymus against multidrug-resistant A. Baumannii infection. Materials and Methods: Cynara scolymus hydroalcoholic extract in comparison with gentamicin antibiotics on clinical strains as well as pathogenic bacteria such as Multidrug-Resistant Acinetobacter Baumannii, under in vitro conditions using micro broth dilution and disc diffusion methods. Moreover, minimum inhibitory concentration and Minimum bactericidal concentration of its hydroalcoholic extract was also evaluated. Results: The results showed that although Cynara scolymus extract was effective on Multidrug-Resistant Acinetobacter Baumannii. The extract was also tested in the form of topical administration on excision wound model in rats. In the extract-treated wounds, the wound healing percent was significantly increased in comparison with controls. Conclusions: Based on this research, herbal extract of Cynara scolymus can be a great candidate for the treatment of Multidrug-Resistant Acinetobacter Baumannii infections and merits further studies.
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