Bulletin of Stomatology and Maxillofacial Surgery
ISSN 1829-006X
2025; 462–468
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EXPLORING THE ROLE OF STEM CELLS IN REGENERATIVE DENTISTRY AND THERAPEUTIC APPLICATIONS: A COMPREHENSIVE REVIEW

Salma Abubaker Ali*, Malaz Mustafa, Weam Ibrahim

College of Dentistry, King Khalid University, Abha, Saudi Arabia · College of Dentistry, King Khalid University, Abha, Saudi Arabia. · King Khalid University, Abha, Saudi Arabia

Received: 2026-04-08 · Published: 2025-11-21

© 2025 The Author(s) and the original publisher.

CC BY-NC 4.0 This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
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Original title
EXPLORING THE ROLE OF STEM CELLS IN REGENERATIVE DENTISTRY AND THERAPEUTIC APPLICATIONS: A COMPREHENSIVE REVIEW
Authors
Salma Abubaker Ali, Malaz Mustafa, Weam Ibrahim
Source journal
Bulletin of Stomatology and Maxillofacial Surgery
Published
2025-11-21
Licence
Creative Commons Attribution-NonCommercial 4.0 International
Original
https://doi.org/10.58240/1829006X-2025.21.10-462

Abstract

Stem cells are components of developing and mature tissues, where they are involved in the self-healing and selfrepair of the body. Scientists have directed significant efforts toward investigating their possible applications in treating different diseases in the last few years. Self-replication and differentiation characterizes these cells into a variety of special somatic cells, making them ideal for future clinical therapy, drug discovery, and biomedical research. Currently, five macroscopically distinguishable subgroups of dental pulp have been described: dental pulp stem cells (DPSCs), stem cells extracted from exfoliated deciduous teeth (SHED), stem cells generated from apical papilla (SCAP), periodontal ligament stem cells (PDLSCs), and dental follicle precursor cells (DFPCs). They are easy to obtain, live, and multipotent. Therefore, the isolation and use of these cells in a safe, efficient, and inexpensive manner is an important area of investigation. Interestingly, jaw, facial, and oral cavity tissues are rich sources of stem cells that are more accessible than other sources. Consequently, stem cell-based and tissue engineering applications in dentistry have gained increasing interest and clinical relevance in the recent years. This review is prepared to attract attention to the uniqueness of DSCs and their different functional roles, and to assess their clinical translational potential. The recent discovery of their ability to regenerate has provided great impetus for future investigations of their potential therapeutic use in a variety of conditions.
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