Abstract

Coronaviruses are a large family of viruses that cause disease ranging from the common cold to more severe cases such as Middle East Respiratory Syndrome and severe acute respiratory syndrome. Coronaviruses have been determined to be responsible for approximately 15% of upper respiratory tract infections in adults. Severe acute respiratory syndrome can cause severe pneumonia, with mortality approaching 10%. In 2019, novel coronavirus (COVID-19) has spread rapidly in Wuhan, Hubei Province, China. The first cases were strongly associated with the Huanan seafood market, where animals were sold for food. As of March 2020, the number of affected countries has tripled with 203,613 cases in over 114 countries and caused far higher morbidity and mortality than either Severe Acute Respiratory Syndrome or Middle East Respiratory Syndrome despite rapid identification and robust public health measures. However, genomic research has provided evidence that the virus was introduced to the market from a different, yet unknown location, although human-to-human transmission may have occurred earlier. COVID19 caused far higher morbidity and mortality than either (severe acute respiratory syndrome) or (Middle East respiratory syndrome) despite rapid identification and robust public health measures disease severity independently predicted the composite endpoint. New therapies and clinical trials are needed for tracking the evolution of severe acute respiratory syndrome and limit the spread of the disease.

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