The New Armenian Medical Journal Vol.13 (2019), Nо 1
2019; 40–47
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Helicobacter Pylori DENSITY AND EXPRESSION OF GASTRIC MUCOSAL INTERLEUKIN-8 IN DYSPEPTIC PATIENTS

Iswan Abbas Nusi*

Received: 2025-08-13 · Published: 2019-10-01

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Original title
Helicobacter Pylori DENSITY AND EXPRESSION OF GASTRIC MUCOSAL INTERLEUKIN-8 IN DYSPEPTIC PATIENTS
Author
Iswan Abbas Nusi
Source journal
The New Armenian Medical Journal Vol.13 (2019), Nо 1
Published
2019-10-01
Licence
as stated by the publisher
Original
https://ysmu.am/v2/wp-content/uploads/2023/09/6.-Ismarini-NAMJ-Vol-13-No-1.pdf

Abstract

Background: The density of the H. pylori colonies is associated with more severe clinical manifestations, chronic infections, ineffective therapy responses and malignant events. Interleukin-8 (IL-8) is one of cytokines that plays a role in the inflammatory process that results in gastric mucosal damage. We determined the association between H. pylori density and gastric mucosal IL-8 expression in dyspeptic patients. Methods: H. pylori density was determined using histopathology based on Updated Sydney System. IL-8 levels were measured using immunohistochemistry from the gastric biopsy. Results: There was significant difference between gastric mucosal IL-8 expression obtained in gastric mucosal gland epithelium (p = 0.028) at mild and high density of H. pylori (p = 0.013). There was a correlation between H. pylori density with gastric mucosal IL-8 expression of glandular epithelium (r = 0.622; p = 0.004), surface epithelium (r = 0.510; p = 0.026), and inflammatory cells (r = 0.054; = 0.028). Conclusion: We found a significant positive correlation between H. pylori density and gastric mucosal IL-8 expression in dyspeptic patients.
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