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The article discusses the importance and necessity of studying blood system one of the most significant functional systems of the body during hypoxia. Under conditions of repetitive (within 3 days) acute hypobaric hypoxia, shifts in the hematological parameters of rabbits were revealed. The study of physiological mechanisms and, especially, the use of preventive measures such as antioxidants can ensure the safe functioning of a body in unfavorable hypoxic conditions. The article considers the use of alpha-tocopherol as a strong immunomodulator to mitigate negative changes in the hematological system caused by hypoxia.