Bulletin of Stomatology and Maxillofacial Surgery
2025; 268–276
Shared with The Gufo

HEMOSTASIS ACHIEVEMENT REFLECTING THE INFLAMMATORY STATUS OF THE PULP BASED ON CYTOKINE LEVELS: A COHORT STUDY

Samah Mohsin Megahed*

Received: 2025-10-03 · Published: 2025-08-06

© 2025 The Author(s) and the original publisher.

CC BY-NC 4.0 This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Shared article.
Original title
HEMOSTASIS ACHIEVEMENT REFLECTING THE INFLAMMATORY STATUS OF THE PULP BASED ON CYTOKINE LEVELS: A COHORT STUDY
Author
Samah Mohsin Megahed
Source journal
Bulletin of Stomatology and Maxillofacial Surgery
Published
2025-08-06
Licence
Creative Commons Attribution-NonCommercial 4.0 International
Original
https://doi.org/10.58240/1829006X-2025.21.7-268

Abstract

Aim:To investigate whether hemostasis at the exposure site reflect the level of inflammation at canal orifices of primary teeth with carious pulp exposures through measuring the cytokines levels at the exposure sites and canal orifices. Materials and methods:This study was conducted on (30) children aged 5-7 years with deep carious lesions in their primary molars. It included 41 carious primary molars at which hemostasis at the exposure site was achieved within five minutes (group I), and 41 carious primary molars at which hemostasis at the exposure site was not achieved within five minutes but was achieved at the canal orifice within five minutes (group II). To assess inflammatory markers at the exposure site and canal orifice, a pulpal blood samples were analyzed for IL-2, IL-6 and IL-8 levels (pg/ml) using ELISA. Data were statistically analyzed. Results: The levels of IL-2, IL-6 and IL-8 at the exposure site in group (I) revealed significantly difference between all interleukins (P<0.0001). The levels of IL-8 in group (I) at the canal orifice, group (II) at the exposure site and at the canal orifice showed significantly the lowest while it revealed insignificant difference between IL-2 and IL-6. Conclusions:IL-2, IL-6 and IL-8 cytokine expression in primary molars increased in exposure sites and increases with caries progression at canal orifices.
1 / ? 100% Open in new tab Download Cite

Loading the full text…

Download Follow Updates