The vascular wall endothelium is a metabolically active tissue whose dysfunction is a mandatory pathogenetic link in almost all cardiovascular diseases: coronary heart disease, hypertension, chronic heart failure, atherosclerosis, etc.
There is no doubt that the altered functional activity of vascular wall endothelial cells requires the active monitoring and correction. Given the high degree of comorbidity and pharmacological (drug) load of patients with cardiovascular diseases, and sometimes polypragmasia, it is advisable to use non-drug (complementary) methods of correcting endothelial functions in this group of patients.
The studied influence of terahertz electromagnetic waves at the frequencies of 150.176-
150.664 GHz on the altered functional activity of the vascular wall endothelium was in the experiment. For its evaluation, the level of biologically active substances of endothelial origin that primarily affect vascular tone was studied: endothelial NO-synthase, endothelin-1, asymmetric dimethylarginine, the total concentration of nitrite/nitrate ions, which is a generally recognized method for evaluating the activity of nitric oxide production.
Irradiation of experimental animals was made with electromagnetic waves at the frequencies of nitric oxide 150.176-150.664 GHz on a skin area of 3 cm above the xiphoid process of the sternum. The emitter of electromagnetic waves was located at a distance of 1.5 cm above the surface of the animal’s body. We used a “NO” emitter with a radiation power of 0.7 mW, the power density falling on a skin area of 3 cm in size was equal to 0.2 mW/cm2. For irradiation of animals, a portable medical device of terahertz therapy “Orbit” was used the radiation dose was determined by the power density falling on the skin and the specified irradiation time. The duration of a single exposure was 15 and 30 minutes.
It was indicated that 15-minute exposure to terahertz waves leads to partial normalization of the profile of endothelium-dependent biologically active substances, and at 30 minute exposure, there is a complete statistically significant recovery of the concentration of biologically active substances produced by the endothelium.
Basing on the data achieved, it is reasonable to recommend the complementary use of terahertz electromagnetic waves at nitrogen oxide frequencies to correct altered endothelial functions.
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