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Abstract
Background: Periodontitis is a multifactorial inflammatory disease leading to progressive destruction of toothsupporting tissues. Advances in periodontal therapy have introduced novel adjunctive and regenerative approaches.
Objective: To systematically evaluate modern treatment strategies for periodontitis published between 2020 and 2025.
Methods: A systematic search was conducted following PRISMA 2020 guidelines across PubMed, Scopus, and Web of Science databases. Studies evaluating non-surgical, pharmacological, laser-based, probiotic, and regenerative therapies were included. Risk of bias and study quality were assessed.
Results: A total of 249 records were identified, of which 60 studies met inclusion criteria. Scaling and root planing (SRP) remains the gold standard, while adjunctive therapies such as local antimicrobials, systemic antibiotics, probiotics, laser therapy, and platelet concentrates significantly improved clinical outcomes. Regenerative techniques demonstrated promising results in advanced defects.
Conclusion: Modern periodontal therapy emphasizes a multimodal and personalized approach, integrating conventional and advanced technologies to optimize outcomes.
