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The changes of students’ heart rate parameters during daily academic load, as well as the possibility of their correction with classical music were investigated. It was established that daily academic load leads to disturbance of the sympathetic- parasympathetic balance through an increased activity of parasympathetic mechanisms and development of fatigue. Classical music neutralizes negative effect of daily academic load on the students’ organism functional systems, improves physical and mental efficiency of work, promotes the activation of compensatory-adaptive mechanisms, giving the so-called Mozart effect.