Bulletin of Stomatology and Maxillofacial Surgery
2025; 68–73
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PERIODONTITIS AND UROLOGIC CANCERS: A NARRATIVE REVIEW OF POTENTIAL RISK CONNECTIONS

Savio Domenico Pandolfo*, Giuseppe Minervini, Achille Aveta, Ugo Amicuz, Federico Capone, Paolo Conforti, Gianluca Spena, Francesco Passaro, Alessandro Izzo

Department of Urology, University of L’Aquila, 67100 L’Aquila, Italy · Multidisciplinary Department of Medical-Surgical and Dental Specialties, University of Campania ‘Luigi Vanvitelli’, 80138 Naples, Italy · Department of Urology, Istituto Nazionale Tumori, IRCCS, "Fondazione G. Pascale", 80131 Naples, Italy · Department of Neurosciences and Reproductive Sciences and Odontostomatology, University of Naples “Federico II”, 80131 Naples, Italy

Received: 2025-10-03 · Published: 2025-08-05

© 2025 The Author(s) and the original publisher.

CC BY-NC 4.0 This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
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Original title
PERIODONTITIS AND UROLOGIC CANCERS: A NARRATIVE REVIEW OF POTENTIAL RISK CONNECTIONS
Authors
Savio Domenico Pandolfo, Giuseppe Minervini, Achille Aveta, Ugo Amicuz, Federico Capone, Paolo Conforti, Gianluca Spena, Francesco Passaro, Alessandro Izzo
Source journal
Bulletin of Stomatology and Maxillofacial Surgery
Published
2025-08-05
Licence
Creative Commons Attribution-NonCommercial 4.0 International
Original
https://doi.org/10.58240/1829006X-2025.21.7-68

Abstract

Urologic cancers, including prostate, bladder, and kidney cancers, represent a major global health burden with complex and multifactorial etiologies. An infectious inflammatory illness called periodontitis has been increasingly implicated in systemic conditions like cancer Mechanisms involving oxidative stress, disruption of the immune system, systemic inflammation, and body microbiome modulation are likely accountable for these correlations. We detail recently established correlations among urologic cancers and periodontitis, with emphasis upon systemic inflammation as an important common pathway, in this review. The correlation between oral diseases and cancer risk suggests multidisciplinary research potentially could define these correlations and provide focused therapies Clinically, periodontal evaluation inclusion in general cancer risk profiling potentially could deliver new directions in patient care prevention.
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