Abstract

Parkinson's (PD) disease is a common movement disorder in a wide range of neurodegenerative diseases, often associated with gradual personality degradation. The major reason for PD is the progressive disturbance of dopaminergic neurons of the substantia nigra pars compacta. Therefore, therapy aimed at slowing the death of dopaminergic neurons can be effective. In the treatment of neurodegenerative diseases, various kinds of neuroprotectors are successfully used, after which the recovery of lost functions of the central nervous system is accelerated. In the present study, bacterial melanin was used for this purpose. A comparative study of the morphofunctional state of the cell structures of the compact substantia nigra in rats was conducted on the rotenone model of PD and in combination with the administration of bacterial melanin. For the morphological and histochemical study, we used the method of detecting the activity of Ca2 + - dependent acid phosphatase. The data analysis showed that during rotenone intoxication of the brain, neuronal death and substantia nigra depigmentation are observed, sharp morphological changes in intracellular structures occur, which indicates gross metabolic and morphological disorders. With the introduction of bacterial melanin, there is a tendency to preserve the typical morphological picture of the neurons of the substantia nigra pars compacta compared to the model of PD. Obtained data give reason to suggest bacterial melanin acts as a neuroprotective agent.

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