Bulletin of Stomatology and Maxillofacial Surgery
ISSN 1829-006X
2025; 198–205
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RARE EARTH ELEMENT-DOPED BIOGLASS FOR PERIODONTAL REGENERATION; AN IN VITRO INVESTIGATION OF BIOCOMPATIBILITY AND REGENERATIVE POTENTIAL

Poulami Chakraborty*, Nidhita Suresh, Kaarthikeyan Gurumoorth

Department of Periodontics, Saveetha Dental college, Saveetha Institute of Medical and Technical Sciences, Saveetha University 162, Poonamallee High Road, Chennai, India, · Department Of Periodontics, Saveetha dental college, Saveetha Institute Of Medical And Technical Sciences, Saveetha University 162, Poonamallee High Road, Chennai, India, · , Department Of Periodontics, Saveetha dental college, Saveetha Institute Of Medical And Technical Sciences, Saveetha University 162, Poonamallee High Road, Chennai, India,

Received: 2026-04-08 · Published: 2025-03-30

© 2025 The Author(s) and the original publisher.

CC BY-NC 4.0 This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
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Original title
RARE EARTH ELEMENT-DOPED BIOGLASS FOR PERIODONTAL REGENERATION; AN IN VITRO INVESTIGATION OF BIOCOMPATIBILITY AND REGENERATIVE POTENTIAL
Authors
Poulami Chakraborty, Nidhita Suresh, Kaarthikeyan Gurumoorth
Source journal
Bulletin of Stomatology and Maxillofacial Surgery
Published
2025-03-30
Licence
Creative Commons Attribution-NonCommercial 4.0 International
Original
https://doi.org/10.58240/1829006X-2025.3-198

Abstract

Background: Periodontitis is a chronic inflammatory disease that causes progressive destruction of periodontal structures, including the alveolar bone, cementum, and periodontal ligament. Restoring these tissues remains a key challenge in periodontal therapy. Bioactive glass has shown potential for periodontal regeneration due to its osteoinductive and osteoconductive properties. Recently, ion doping has been explored to enhance its regenerative effects, with erbium-doped bioglass (Er-BG) gaining attention for promoting osteogenic differentiation. This study evaluates the physicochemical properties, biocompatibility, and regenerative potential of Er-BG for periodontal tissue repair. Material and Methodology: Er-BG was synthesized using the sol-gel method. Structural and compositional characterization was performed using Scanning Electron Microscopy (SEM), Energy Dispersive X-ray Spectroscopy (EDS), X-ray Diffraction (XRD), and Attenuated Total Reflectance Infrared Spectroscopy (ATR-IR). Biocompatibility and osteogenic potential were assessed using human periodontal ligament stem cells (PDLSCs) through MTT, Alkaline Phosphatase (ALP), collagen estimation, and calcium deposition assays. Zebrafish embryo models were used for toxicity evaluation. Results: SEM revealed a porous surface facilitating cell attachment. EDS confirmed erbium integration, while XRD indicated an amorphous structure. Er-BG enhanced ALP activity (~130%), collagen synthesis (~105%), and calcium deposition (~145%). Zebrafish studies confirmed minimal cytotoxicity. Conclusion:Er-BG demonstrated excellent biocompatibility, osteogenic potential, and low toxicity, making it a promising candidate for periodontal regeneration. Further in vivo studies are needed.
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