Bulletin of Stomatology and Maxillofacial Surgery
2025; 140–143
Shared with The Gufo

RECURRENT APHTHOUS STOMATITIS IN A PATIENT WITH WILSON’S DISEASE: A CASE REPORT

Swedha Ramamurthy*, Beena Varama, Renju Jose

POSTGRADUATE, DEPARTMENT OF ORAL MEDICINE AND RADIOLOGY, AMIRTA SCHOOL OF DENTISTRY , INDIA · PROFESSOR EMERITUS, AMRITA SCHOOL OF DENTISTRY, INDIA · HEAD OF DEPARTMENT, AMRITA SCHOOL OF DENTISTRY, INDIA

Received: 2025-09-25 · Published: 2025-08-31

© 2025 The Author(s) and the original publisher.

CC BY-NC 4.0 This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Shared article.
Original title
RECURRENT APHTHOUS STOMATITIS IN A PATIENT WITH WILSON’S DISEASE: A CASE REPORT
Authors
Swedha Ramamurthy, Beena Varama, Renju Jose
Source journal
Bulletin of Stomatology and Maxillofacial Surgery
Published
2025-08-31
Licence
Creative Commons Attribution-NonCommercial 4.0 International
Original
https://doi.org/10.58240/1829006X-2025.21.8-140

Abstract

Background:Wilson’s disease (WD) is a rare autosomal recessive disorder of copper metabolism caused by ATP7B gene mutations. Recurrent aphthous stomatitis (RAS) is a common, multifactorial oral mucosal disorder. Their coexistence is uncommon and has been scarcely reported in the literature. Objectives: This case report aims to describe the clinical features, management, and possible association between RAS and WD, highlighting the importance of treatment adherence and interdisciplinary care. Materials and Methods: A 26-year-old male with a known history of WD under zinc therapy presented with recurrent oral ulcerations and gingival bleeding. Detailed history, clinical examination, and follow-up assessments were performed to evaluate the nature of lesions and their correlation with treatment compliance. Results: Clinical examination revealed two minor aphthous ulcers on the lower labial mucosa with associated generalized gingival erythema. Ulcer recurrences correlated with poor adherence to zinc therapy. Complete healing was observed after resuming therapy, with no recurrence at one-month follow-up. Conclusion: This case highlights a possible link between WD and RAS, potentially mediated by micronutrient imbalance and immune dysregulation. Strict adherence to therapy and interdisciplinary management are crucial for preventing recurrences and maintaining oral health in WD patients.
1 / ? 100% Open in new tab Download Cite

Loading the full text…

Download Follow Updates