Bulletin of Stomatology and Maxillofacial Surgery
ISSN 1829-006X
2025; 369–379
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STUDY OF THE ОRAL CAVITY AND DETERMINATION OF THE LEVEL OF PRO-INFLAMMATORY IL-2 AND ɤ-INF IN ORAL FLUID OF PATIENTS WITH VIRAL HEPATITIS C BEFORE AND AFTER COMPLEX TREATMENT

Seda Geghamyan*, Lazar Yessayan, Alvard Hovhannisyan, Gayane Melik-Andreasyan, Vahe Azatyan

Yerevan State Medical University after M. Heratsi, Yerevan, Armenia · Head of Department of Therapeutic Stomatology of Yerevan State Medical University after M. Heratsi, Yerevan, Armenia · Аssociate professor of Department of Infection Diseases of Yerevan State Medical University after M. Heratsi, Yerevan, Armenia · Professor, National Center of Disease Control and Prevention, Ministry of Health RA, Yerevan, Armenia · Department of Therapeutic Stomatology of Yerevan State Medical University after M. Heratsi, Yerevan, Armenia

Received: 2026-04-08 · Published: 2025-06-30

© 2025 The Author(s) and the original publisher.

CC BY-NC 4.0 This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
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Original title
STUDY OF THE ОRAL CAVITY AND DETERMINATION OF THE LEVEL OF PRO-INFLAMMATORY IL-2 AND ɤ-INF IN ORAL FLUID OF PATIENTS WITH VIRAL HEPATITIS C BEFORE AND AFTER COMPLEX TREATMENT
Authors
Seda Geghamyan, Lazar Yessayan, Alvard Hovhannisyan, Gayane Melik-Andreasyan, Vahe Azatyan
Source journal
Bulletin of Stomatology and Maxillofacial Surgery
Published
2025-06-30
Licence
Creative Commons Attribution-NonCommercial 4.0 International
Original
https://doi.org/10.58240/1829006X-2025.21.5-369

Abstract

Background: Interest in the study of combined pathology in recent times is explained by the accumulation of new facts, the emergence of new information on interorgan, intertissue and intercellular levels of interaction in the system of the whole organism. In this regard, the issue of the relationship between diseases of internal organs and organs of the oral cavity is relevant Тhe aim of the study was to examine the condition of the oral cavity and the level of proinflammatory IL-2 and ɤ-INF in the oral fluid of patients with viral hepatitis C before and after complex treatment. Material and methods: The study involved 96 patients with HCV with lesions of the oral mucosa and periodontium, as well as 100 patients of the control group without HCV. All patients had their dental status and index assessment of the periodontal tissue condition studied. Cytokines IL-2, ɤ-INF were determined in the oral fluid. All indicators were studied before and after complex treatment and compared with each other. Results: Objective examination of the oral cavity of patients with HCV revealed the presence of a generalized inflammatory process in the alveolar part of the gums, as well as damage to the OM (p<0.001). In HCV, proinflammatory IL-2 significantly increases, and ɤ-INF increases, but not statistically significantly (p>0.113). After complex treatment, statistically significant improvements are observed in the OM and alveolar part of the gum (p<0.001). Pro-inflammatory IL-2 decreased (p<0.001), and ɤ-INF decreased, but statistical significance is not observed (p>0.121). Conclusion: Thus, a comparative study of lesions of the OM and alveolar part of the gingiva before and after the complex treatment for HCV revealed that the main pathognomonic symptoms reliably undergo dynamics towards improvement and are detected with a lower frequency. When comparing the results of interleukin levels in the OF before and after HCV treatment, a decrease in the level of proinflammatory IL-2 is noted, the level of ɤ-INF also decreases (but the difference in the data is insignificant). Further studies are needed to better understand the level of IL-c in patients with HCV and its relationship with damage to the oral mucosa and periodontium.
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