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SYNTHESIS OF NEW 3-CYANOPYRIDINE-2(1H)-ONES WITH UNSATURATED SUBSTITUENTS AT C-4

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CC BY-NC 4.0 This work is licensed under Creative Commons Attribution–NonCommercial International License (CC BY-NC 4.0).

Abstract

3-Cyanopyridine-2(1H)-ones containing unsaturated substituents at the position C-4 and various substituents at N-1 of the ring have been synthesized as new potential bioactive compounds by interaction of ethyl ylidene cyanoacetate with dimethylformamide dimethyl acetal, and simultaneous reamination-cyclization of obtained derivatives with amines to targeted 3-cyanopyridine-2(1H)-ones.

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