SYNTHESIS OF SOME S-DERIVATIVES OF 1,2,4-TRIAZOLES

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SYNTHESIS OF SOME S-DERIVATIVES OF 1,2,4-TRIAZOLES T.V. Chochikian

The reactions of 5-merkapto-3,4-disubstituted-1,2,4-triazoles with ethyl chloroacetate have been investigated. It has been shown that mercapto group reacted and S-substituted derivatives were formed. On the next step hydrazinolysis by 85% hydrazine hydrate was carried out and on the base of obtained hydrazides thiosemicarbazides were synthesized. Further by means of intermolecular cyclization bis-1,2,4-triazoles were obtained, structure of heterocyclic rings were connected by thio-methyl bridge.

DOI: 10.46991/PYSUB.2016.50.2.008 Chemical and Biological Sciences 50 (2 (240) 8-12

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Keywords

1,2,4-triazoles, hydrazinoles, thiosemicarbazides, bis-triazoles

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