Bulletin of Stomatology and Maxillofacial Surgery
ISSN 1829-006X
2025; 56–63
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THE ROLE AND SIGNIFICANCE OF MYRIAD MATRIX SOFT TISSUE BIO-SCAFFOLD IN ORAL CAVITY TISSUE RECONSTRUCTION POST -CANCER SURGERY-CASE SERIES

Elengkumaran Sankaran*, Ravindran Chinnasamy, Jai Balraj, Pugazhendhi, Saravanan Sekaran, Deepavalli Arumuganainar

Associate professor, Department of Oral and maxillofacial Surgery, Sri Ramachandra Dental College and Hospital, Sri Ramachandra Institute of Higher Education and Research, Porur, Chennai, Tamil Nadu- 600116, India · Professor and Head, Department of Oral and Maxillofacial Surgery, Sri Ramachandra Dental College and Hospital, Sri Ramachandra Institute of Higher Education and Research, Porur, Chennai, Tamil Nadu- 600116, India, · Department of Oral and Maxillofacial Surgery, Sri Ramachandra Dental College and Hospital, Sri Ramachandra Institute of Higher Education and Research, Porur, Chennai, Tamil Nadu- 600116, India · Reader, Department of Prosthodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha Sciences, University, Chennai- 600077, Tamil Nadu, India, · Department of Periodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Saveetha University, Chennai- 600077, Tamil Nadu, India,

Received: 2026-04-08 · Published: 2025-05-15

© 2025 The Author(s) and the original publisher.

CC BY-NC 4.0 This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
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Original title
THE ROLE AND SIGNIFICANCE OF MYRIAD MATRIX SOFT TISSUE BIO-SCAFFOLD IN ORAL CAVITY TISSUE RECONSTRUCTION POST -CANCER SURGERY-CASE SERIES
Authors
Elengkumaran Sankaran, Ravindran Chinnasamy, Jai Balraj, Pugazhendhi, Saravanan Sekaran, Deepavalli Arumuganainar
Source journal
Bulletin of Stomatology and Maxillofacial Surgery
Published
2025-05-15
Licence
Creative Commons Attribution-NonCommercial 4.0 International
Original
https://doi.org/10.58240/1829006X-2025.21.4-56

Abstract

Reconstruction of the soft tissue defects post cancer surgery remains a significant clinical challenge due to the hostile environment of the oral cavity, characterised by polymicrobial colonization, constant movement and presence of high moisture levels persistently. Conventional techniques like the split-thickness grafts and pedicled grafts have been widely used. However, they entail donor site morbidity, prolonged surgical time and variable esthetic and functional outcomes. The Myriad matrix, a decellularized ovine forestomach matrix (OFM), represents a novel biologically active scaffold that supports rapid tissue integration, angiogenesis, and epithelialization. This case series presents two patients with histopathologically confirmed oral squamous cell carcinoma (OSCC) involving the right buccal mucosa and the lateral aspect of the tongue. Both the patients underwent oncologic resection, followed by soft tissue reconstruction using the Myriad matrix soft tissue bio-scaffold. In both the cases, the matrix contributed a stable scaffold for closure, eliminated the need for autologous tissue harvesting, and allowed for complete mucosalization of the defect site. Postoperative follow-up revealed excellent healing, with no evidence of graftrelated complications. Functional recovery, including speech, deglutition, and tongue mobility, was well reestablished. These findings emphasize the clinical advantages of OFM in oral tissue reconstruction, highlighting its reliability, ease of use, and regenerative potential. The Myriad matrix may thus serve as a valuable alternative in reconstructive strategies, particularly in resource-limited surgical settings.
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