Reconstruction of the soft tissue defects post cancer surgery remains a significant clinical challenge due to the hostile
environment of the oral cavity, characterised by polymicrobial colonization, constant movement and presence of
high moisture levels persistently. Conventional techniques like the split-thickness grafts and pedicled grafts have
been widely used. However, they entail donor site morbidity, prolonged surgical time and variable esthetic and
functional outcomes. The Myriad matrix, a decellularized ovine forestomach matrix (OFM), represents a novel
biologically active scaffold that supports rapid tissue integration, angiogenesis, and epithelialization. This case series
presents two patients with histopathologically confirmed oral squamous cell carcinoma (OSCC) involving the right
buccal mucosa and the lateral aspect of the tongue. Both the patients underwent oncologic resection, followed by
soft tissue reconstruction using the Myriad matrix soft tissue bio-scaffold. In both the cases, the matrix contributed
a stable scaffold for closure, eliminated the need for autologous tissue harvesting, and allowed for complete
mucosalization of the defect site. Postoperative follow-up revealed excellent healing, with no evidence of graftrelated complications. Functional recovery, including speech, deglutition, and tongue mobility, was well reestablished. These findings emphasize the clinical advantages of OFM in oral tissue reconstruction, highlighting its
reliability, ease of use, and regenerative potential. The Myriad matrix may thus serve as a valuable alternative in
reconstructive strategies, particularly in resource-limited surgical settings.
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