THERMODYNAMICS OF INTERACTIONS OF CoTOEPyP4 PORPHYRIN WITH A-DNA

Avetisyan Avetisyan

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Abstract

We have employed UV light absorption and circular dichroism methods to study the binding of water-soluble Co(II)-containing meso-tetra-(4N-oxyethylpyridyl) porphyrin (CoTOEPyP4) with B- and A-DNA from Calf Thymus. The binding constant Kb we determined from binding isotherms for each DNA–porphyrin complexes and calculated binding free energy ΔG, enthalpy ΔH and entropy ΔS. Our results suggest that CoTOEPyP4 porphyrin preferably binds via outside self-stacking mode with B- and A-DNA.

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THERMODYNAMICS OF INTERACTIONS OF CoTOEPyP4 PORPHYRIN WITH A-DNA

Abstract

Author(s)

Table of Contents

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THERMODYNAMICS OF INTERACTIONS OF CoTOEPyP4 PORPHYRIN WITH A-DNA

Abstract

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