2014; Chemical and Biological Sciences 48 (3 (235): 40–45
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THERMODYNAMICS OF INTERACTIONS OF CoTOEPyP4 PORPHYRIN WITH A-DNA

A.A. Avetisyan*

Received: 2025-03-10 · Published: 2014-11-14

© 2014 The Author(s) and the original publisher.

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Original title
THERMODYNAMICS OF INTERACTIONS OF CoTOEPyP4 PORPHYRIN WITH A-DNA
Author
A.A. Avetisyan
Published
2014-11-14
Licence
as stated by the publisher

Abstract

We have employed UV light absorption and circular dichroism methods to study the binding of water-soluble Co(II)-containing meso-tetra-(4N-oxyethylpyridyl) porphyrin (CoTOEPyP4) with B- and A-DNA from Calf Thymus. The binding constant Kb we determined from binding isotherms for each DNA–porphyrin complexes and calculated binding free energy ΔG, enthalpy ΔH and entropy ΔS. Our results suggest that CoTOEPyP4 porphyrin preferably binds via outside self-stacking mode with B- and A-DNA.
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