2014; Physical and Mathematical Sciences, 48(1 (233): 51–56
Shared with The Gufo

INFLUENCE OF CATIONIC PORPHYRINS ON MELTING PARAMETERS OF CALF THYMUS DNA

L.R. Aloyan L.R. Aloyan*

Received: 2025-02-17 · Published: 2014-04-10

© 2014 The Author(s) and the original publisher.

CC BY 4.0 This work is licensed under a Creative Commons Attribution 4.0 International License.
Shared article.
Original title
INFLUENCE OF CATIONIC PORPHYRINS ON MELTING PARAMETERS OF CALF THYMUS DNA
Author
L.R. Aloyan L.R. Aloyan
Published
2014-04-10
Licence
Creative Commons Attribution 4.0 International

Abstract

The influence of water soluble cationic 3N- and 4N-pyridyl porphyrins with different peripheral substituents on melting parameters of Calf Thymus DNA has been studied. It was shown, that the presence of porphyrin changes the shape and parameters of DNA melting curve. The decrease of T in the presence of 3N-porphyrins is observed. Because of the intercalation binding mechanism occurs in GC-rich regions of DNA, which is the reason for the decrease melting interval. While even at the low relative concentration for 4N-porphyrins already the external binding mechanism “turns on” and as a result the change in the melting parameters of DNA upon complexation with these porphyrins is not observed.
1 / ? 100% Open in new tab Download Cite

Loading the full text…

Download Follow Updates