2015; Physical and Mathematical Sciences, 49(3 (238): 49–54
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MITOXANTRONE INTERACTION WITH POLY(G)

Karapetyan Karapetyan*

Received: 2025-02-11 · Published: 2015-12-15

© 2015 The Author(s) and the original publisher.

CC BY 4.0 This work is licensed under a Creative Commons Attribution 4.0 International License.
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Original title
MITOXANTRONE INTERACTION WITH POLY(G)
Author
Karapetyan Karapetyan
Published
2015-12-15
Licence
Creative Commons Attribution 4.0 International

Abstract

In the present work the thermodynamic studies of mitoxantrone complexformation with four-stranded poly(G) have been carried out. The binding thermodynamic parameters, the binding constant K and the number of nucleotides corresponding to one binding site n, were determined. It was shown that mitoxantrone is bound stronger with four-stranded poly(G), then it is bound with double-stranded helix. It was also shown that due to difficulties of the intercalation of mitoxantrone molecules into four-stranded structure is bound mainly by external binding mode with [poly(G)]4 and at the interaction saturation mitoxantrone bound to much more guanines (n≅10) per one molecule.
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