2009; Physical and Mathematical Sciences, 43(2 (219): 55–59
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THE INTERACTION OF Ag-CONTAINING PORPHYRINS WITH DNA AT HIGH IONIC STRENGTH

Ye. B. Dalyan*

Received: 2025-02-28 · Published: 2009-06-26

© 2009 The Author(s) and the original publisher.

CC BY 4.0 This work is licensed under a Creative Commons Attribution 4.0 International License.
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Original title
THE INTERACTION OF Ag-CONTAINING PORPHYRINS WITH DNA AT HIGH IONIC STRENGTH
Author
Ye. B. Dalyan
Published
2009-06-26
Licence
Creative Commons Attribution 4.0 International

Abstract

UV-VIS spectrophotometry and circular dichroism (CD) methods were applied to study the binding of DNA with three novel Ag-containing porphyrins meso-tetra(4N-allylpyridyl) (AgTAlPyP4), meso-tetra(4N-butylpyridyl) (AgTButPyP4) and meso-tetra(4N-oxyethylpyridyl) (AgTOEtPyP4) at high ionic strength. The binding constant Kb and stoichiometry n were determined from binding isotherms for each ligand–DNA complex. The Gibbs free energy, enthalpy and entropy of binding also were calculated using the values of Kb . Obtained results show that these porphyrins associate with the duplex DNA via outside binding mode.
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